An 18 year old girl named Drew Decker (Carmen Electra) receives a threatening phone call while home alone one night. Drew is chased outside by Ghostface, who wounds her with a stab to the breast that removes her implant. She is hit by a car driven by her father who was distracted by oral sex from his wife, then killed by Ghostface.

The next day, Cindy Campbell (Anna Faris) meets up with her boyfriend Bobby Prinze (Jon Abrahams) and her friends, Brenda Meeks (Regina Hall), Ray Wilkins (Shawn Wayans), Greg Phillipe (Lochlyn Munro), and Buffy Gilmore (Shannon Elizabeth). Various news teams, including hack reporter Gail Hailstorm (Cheri Oteri), converge on the school in the wake of Drew’s death. Gail hooks up with Buffy’s mentally disabled brother “Special Officer” Doofy (Dave Sheridan) hoping to milk the facts out of him….