In 1818, Abraham Lincoln (Benjamin Walker) lives in Indiana with his parents, Nancy (Robin McLeavy) and Thomas (Joseph Mawle), who works at a plantation owned by Jack Barts (Marton Csokas). There, Lincoln befriends a young African American boy, William Johnson (Anthony Mackie), and intervenes when he sees Johnson being beaten by a slaver. Because of his son’s actions, Thomas is fired. That night, Lincoln sees Barts break into his house and attack his mother. Nancy falls ill the following day, and dies shortly afterwards. Thomas tells Lincoln that Barts poisoned her.

Nine years later, a vengeful Lincoln attacks Barts at the docks, but Barts, who is actually a vampire, overpowers him. However, before Barts can kill him, Lincoln is rescued by Henry Sturges (Dominic Cooper). Sturges explains that vampires exist, and offers to teach Lincoln to be a vampire hunter…