After giving a guest lecture on criminal psychology at a local university, Dr. Helen Hudson (Weaver), a respected field expert on serial killers, is cornered in a lavatory by one of her previous subjects, Daryll Lee Cullum (Harry Connick, Jr.), who kills a police officer and brutally attacks her. Helen becomes severely agoraphobic as a result, sealing herself inside an expensive hi-tech apartment, conducting her entire life from behind a computer screen and assisted by a friend, Andy (John Rothman).

When a new series of murders spread fear and panic across her home city of San Francisco, detective M.J. Monahan (Hunter) and her partner Reuben Goetz (Dermot Mulroney) solicit Helen’s expertise. Initially reluctant, Helen soon finds herself drawn into the warped perpetrator’s game of wits…